Hiro Clinic NIPT
Have you heard about ADD, the new NIPT? ADD is an exclusive Hiro Clinic NIPT test for partial deletions and duplications in all autosomal regions. Have you heard about ADD, the new NIPT? ADD is an exclusive Hiro Clinic NIPT test for partial deletions and duplications in all autosomal regions.
NIPT chosen by 30,000 pregnant women
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Hiro Clinic NIPT
Survey of examinee satisfaction!

「2024年7月NIPT(新型出生前診断)に対する満足度」に関するアンケート調査を実施しました

Differences between Early NIPT and Early Next Generation NIPT

Early NIPT Early Next Generation NIPT
Executing authority General obstetrics and gynecology Hiro Clinic
Target Basically only for high-risk persons Anyone can take the test
Number of weeks 10 weeks~ After confirmation of pregnancy by echo
Approximately 6 weeks
In charge Counsellor Doctor
Inspection
checklist
Chromosome 21,18,13 trisomy Chromosome 21,18,13 trisomy
Sex chromosome aneuploidy
Autosomal heterozygosity
Partial deletion-duplication
Microdeletions (4 types)
Single-gene diseases (228 types)
Amniotic diagnosis
test
Referral to almost all university hospitals Referral to collaborating clinics
Patient’s preferred inspection location
(Assisted amniotic fluid support available)
Chosen by 40,000 pregnant women

Reason 01 for choosing us

Test results in as little as two days.

Comparative table of test results

Hiro Clinic provides fast test results to reduce anxiety during an unstable pregnancy, as well as a prompt result report on positive NIPT test results, allowing for a smooth transition to the next test. Patient reassurance and trust are our top priority, and we will do our utmost to support healthy mothers and babies.

Reason 02 for choosing us

In-country inspections with low transport risk

Comparative table of inspection countries

Hiro Clinic cooperates with the Tokyo Sanitary Laboratory, which is located in Japan. Typical clinics transport specimens abroad, which increases the likelihood of problems occurring during transit. Because Hiro Clinic cooperates with national laboratories, there is less risk of transport.

Reason 03 for choosing us

Wide range of inspection items

Items available for inspection

Hiro Clinic also offers more in-depth testing so that diseases that may develop after birth or are difficult to detect can be tested for in advance. We will help you to feel safe and secure during the birth of your baby.

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ヒロクリニックNIPTは従来よりもさらに詳しく検査することができます!

What is Early NIPT?

Until now, Hiro Clinic has conducted the NIPT test after 10 weeks, when there are worldwide publications on the test and its validity is guaranteed.
When the Tokyo Health Laboratory, which carries out the tests at the hospital, carried out random tests on pregnant women of less than 10 weeks without checking the number of weeks, the test results were available for all of them.

NIPT has been recommended after 10 weeks, when a sufficient amount of foetal DNA (FF ‘Fetal fraction’) in maternal blood is considered detectable.
This clinical experiment at the Tokyo Sanitary Laboratory proved that a sufficient amount of foetal DNA (FF ‘Fetal fraction’) in maternal blood can be detected at less than 10 weeks.

Therefore, Hiro Clinic offers Early NIPT for pregnant women under 10 weeks, when the foetal heartbeat has been confirmed.
However, to ensure the accuracy of the test, a second test is strongly recommended after 10 weeks.
※If the Early NIPT test is positive at less than 10 weeks, there is no positive target rate or positive score reported.

NIPT is it really only about the 'number' of chromosomes?
No!!
There are many diseases that cannot be identified by chromosome number alone.

It is not only the ‘number of chromosomes’ that the Hiro Clinic can identify!


Comparison of test contents between other facilities and Hiro Clinic

Comparison of test contents between other facilities and Hiro Clinic
  • ※1 Facilities accredited by the JCMT.
  • ※2 The tests and examinations available vary from facility to facility and are therefore described according to the facility that can do them. All autosomes (chromosomes 1-22) and sex chromosomes.
Here's the difference! NIPT at Hiro Clinic
Full chromosome testing is available!

The NIPT consortium facilities and previous tests
have only tested chromosomes 13, 18 and 21,
1-22, sex chromosomes, etc.
All chromosome counts can be tested.

…but…
Hiro Clinic
does more than that!

Chromosomal structural abnormalities can be tested!

The test not only examines the number of chromosomes,
for example, “three chromosomes 21 means Down’s syndrome”,
but also abnormalities such as missing
or duplicated chromosomes.

Duplicate chromosomes that are multiplied.

Only Hiro Clinic can test for
all autosomal whole-region partial deletions and duplications!

※As of April 2023

検査の費用は? セットプラン

Premium Plan GM

Typical diseases and tests for microdeletions and partial deletions and duplications.

  • ●Informs about abnormality in chromosomes 13, 18 and 21.

    Chromosomes 13, 18 and 21
  • ●Informs about sex chromosome abnormalities and gender.

    Gender determination
  • ●Notification of all autosomal whole-region partial deletions and duplication disease abnormalities.

    Deletion/duplication
  • ●Four types of microdeletions are notified.

    4 species microdeletion

Basic check+Autosomal chromosome disorder with partial loss of all autosomesFind out the partial repeat disorder with full autosomal domain+4 microdeletions.
This is the most popular plan at our clinics.

JPY 239,800(incl. tax JPY 263,780)

(Click for more information)

Premium Plan FM

For those who seek reassurance with all-inclusive inspection details

JPY 279,800(incl. tax JPY 307,780)

(Click for more information)
  • Kleinfelter
  • XXX
  • turner
  • DiGeorge
  • 1p36 deletion
Options
Test Name Remarks Cost (incl. tax)
Ultrasound Test Omiya, Nagoya, and Osaka Clinics, Gynecology only JPY 11,000
Amniocentesis Support One-time payment JPY 3,300
Consultation on Non-Test Days Remote 20 minutes JPY 4,400
Genetic Counseling Remote 20 minutes JPY 4,400
Mailing of Test Results Test results sent by letter pack JPY 3,300
Express Service – Next Day Option Available only at Tokyo Station Clinic. Results will be reported the next day for visits by 9:30 am on Thursdays and Sundays.
Applicable for Premium Plan FM, GM, BM (some content only), Basic Plan A, O, H, F, G.
* Available from 10 weeks 0 days.
* Reservation required by 6 pm the day before.
Phone reception: 0120-95-9381
* Once the next day result option fee is paid, no refunds will be made under any circumstances.
JPY 110,000
Express A Results will be sent within 2 days from the day of blood collection. JPY 33,000
Express B
(Nagoya and Sapporo Clinics)
Results will be sent within 2 days from the day of blood collection. JPY 44,000

※ NIPT tests are considered private medical care and are entirely self-paid, so health insurance cannot be used.
※ Options cannot be used alone.
Please read and agree to the following content before applying.
・ Express service is a method of sending specimens to the laboratory using a combination of air and land transport.
In cases of bad weather, disasters, or social circumstances, the results may not be reported within the express service period.
・ If the results are not reported within 3 days from the day of blood collection, the express service fee will be refunded. The clinic will bear the transfer fee.
Refunds for test interruptions or test fees are not accepted.
・ Even if you apply for the express service in advance, it may not be approved.
・ Even just before specimen shipment, if the results cannot be returned within the express service period due to flight cancellations, etc., a prompt report and refund processing will be carried out.

What is microdeletion syndrome?

Microdeletion syndrome is a condition caused by the deletion of a gene at a specific position in a chromosome.

As the name micro implies, they range in size from 500 000 bases in the smallest cases, and are usually caused by deletions of two to three million bases. The size and position of the deletion determines the severity of the condition and the various symptoms associated with developmental delay, such as mental retardation. Many microdeletion syndromes are also said to be spontaneous and occur regardless of maternal age.

This means that it is not always worth testing in pregnant women of any age, young or old.

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For first-time visitors

Hiro Clinic is by appointment only to ensure that patients are treated with integrity. Please feel free to make an appointment first.

NIPT process

  • 1Online booking

    You can book an appointment by filling in the mandatory fields on the dedicated booking page. You will also be asked to confirm your consent and complete a medical questionnaire.

  • 2Coming to the clinic on the day of the appointment

    Please come to the clinic on the date and time you have booked.

  • 3Medical consultation with doctor

    The doctor will interview the patient and explain about NIPT.

  • 4Drawing blood

    A 10 ml blood sample is taken.

  • 5Payment

    Payment by credit card is accepted.

  • 6Download the test result

    The test results can be downloaded from My Page at a later date. Please wait until displayed.

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What are the diseases of total autosomal whole-region partial deletion/duplication?

It is not uncommon for the disease to go unnoticed before birth or until the child has grown up to a certain extent.

Doctor explaining.

Read more

What specific diseases are there? What specific diseases are there?

Prader-Willi syndrome

It is known that the condition is caused by a missing or duplicated gene in part of chromosome 15. It is characterised by obesity, short stature and strabismus, and delayed language and motor development. It is not said to be hereditary.

Angelman’s syndrome

Like Prader-Willi syndrome, this condition is caused by a missing gene in part of chromosome 15. It is characterised by frequent smiling, a large mouth, a pointed chin and severe mental retardation.

Why only Hiro Clinic can perform ADD? Why only Hiro Clinic can perform ADD? Did you know?

Type of inspection Accuracy and others
are determined by the hygiene laboratory

Although many facilities use major overseas laboratories, such as Verinata,
Hiro Clinic
have signed a contract with the Tokyo Sanitary Laboratory,
a team of genetic experts in Japan,
to tag-team with us.

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What if it turns out to be abnormal? Hiro Clinic offers post-test aftercare.
After care01

Amniotic fluid
testing support system

Although NIPT is a highly accurate test, it is not a ‘definitive’ test and it is recommended that an amniotic fluid test is taken to confirm the results.

For positive chromosomes 1-22 autosomes or sex chromosomes (all chromosomes), assistance is provided for G-band and qf-PCR tests.
For all autosomal whole-region partial deletions and duplication diseases, definitive testing by G-band, qf-PCR, microarray and FISH tests is required.

Amniotic fluid testing support not covered: those who choose Basic Plan H are not eligible for amniotic fluid testing support.

Hiro Clinic NIPT includes amniotic fluid testing support organised by partner institutions(JPY 3,300・incl. tax)※system.
※Membership fees are paid on arrival at the clinic

If the test result is positive,
subsidises the cost of amniotic
fluid
testing up to a maximum of
JPY 200,000 including tax!

After care02

Medical examination
by doctor

A doctor will examine the patient if they wish to be examined (after the NIPT test).
A consultation on the day of the NIPT test is included in the test fee, but a consultation fee of JPY 4,000 (JPY 4,400 incl. tax) is charged for a consultation on a day other than the test day.

If you wish to see a doctor, please call us. Depending on the schedule of your doctor, we will be happy to make an appointment if possible.

Q&A

What diseases can be tested for
with sex chromosome aneuploidy?

Abnormalities in Klinefelter’s syndrome and XXX syndrome, which occur more frequently than Down’s syndrome, can be checked.

What microdeletion syndromes
can be tested for?

Four of the most common syndromes tested for, after Down syndrome, are Di George syndrome, 1p36 deletion syndrome, Smith-Maginnis syndrome and Wolfhirschhorn syndrome.

Which plans are available to check for partial deletions and duplication of disease?

Basic Plan(F・G・B)Premium Plan plans(FM・GM・BM・GM+・FM+)shows all autosomal whole-region partial deletions and duplication disease abnormalities.

What should I do if I test positive?

Hiro Clinic NIPT offers aftercare services such as consultations and assistance with amniotic fluid testing. For more information.

Attention

Notes on NIPT

About Cancellation

Please contact us at least one working day before the inspection date by telephone or using the contact form below.
Changes to appointment dates and times must also be notified at least one working day before the inspection date.
Also, if it is difficult to come to the clinic due to severe morning sickness or other reasons on the day of the visit, please be sure to call the clinic to discuss the situation.
Questions about inspections are handled via an enquiry form on the website.

If the test result is an error

If there is an error in the result, the test will be retested free of charge, but only if there is an error in the technical aspects, such as a low blood sample volume.
This is because the Hiro Clinic NIPT has never had an error in the results and in the event of an error, the testing company has said that there is little point in retesting.
We do not recommend retesting as it is likely to produce the same error.

NIPT is an accurate test with a sensitivity of 99.9% and specificity of 99.90% (median 21st trisomy), but is not a definitive test. If a positive or a decision withheld is followed by a test to confirm the result (amniotic fluid or chorionic villus test).
The test requires proof of current pregnancy. Please bring your maternity record book and an echo-photograph.

Clinic information

NIPT Hiro Clinic
Shinjuku Ekimae

Web Reservation: 24 hours

Opening hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒160-0023 4F Zenken Plaza II, 1-3-13 Nishi-Shinjuku, Shinjuku-ku, Tokyo

03-6258-1882

NIPT Shinjuku Ekimae Clinic (Hiro Clinic) MAP

1 minute walk from Shinjuku Station, Exit D2
1 minute walk from exit A18
3-minute walk from Exit B18, 2-minute walk from Toei Subway Shinjuku Nishiguchi Station Exit
Numerous car parks available
(Affiliated car park: Mitsui Repark Shinjuku L Tower parking lot 1 hour free)

NIPT Hiro Clinic
Omiya Ekimae

Web Reservation: 24 hours

Opening hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒330-0854 2F Fujisawa Building, 2-2-12 Sakuragi-cho, Omiya-ku, Saitama-shi, Saitama Prefecture

048-788-1537

NIPT Omiya Ekimae Clinic (Hiro Clinic) MAP

2-minute walk from Omiya Station West Exit on the JR Keihin Tohoku Line
There are many coin-operated parking spaces nearby
The Repark Omiya Station West Exit parking lot is eligible for a parking discount
You will receive a parking fee service ticket for a maximum of JPY 400
Please check with the reception desk when you visit the clinic

NIPT Hiro Clinic
Tokyo Ekimae

Web Reservation: 24 hours

Opening Hours

【 Monday / Wednesday / Thursday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒104-0031 8F LEO Yaesu Building, 1-1-9 Kyobashi, Chuo-ku, Tokyo

03-6665-0624

NIPT Tokyo Ekimae Clinic (Hiro Clinic) MAP

3-minute walk from Exit 24 of JR Tokyo Station Yaesu Underground Mall
1 min walk from Tokyo Metro Kyobashi Station
Numerous car parks available
(Affiliated car park: Yaesu Parking East parking lot 1 hour free)

NIPT Hiro Clinic
Yokohama Ekimae

Web Reservation: 24 hours

Opening Hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒220-0005 4F 2nd New Yokohama Building, 1-13-10 Minami-Saiwai, Nishi-ku, Yokohama City, Kanagawa Prefecture

045-534-8475

NIPT Yokohama Ekimae clinic (Hiro Clinic) MAP

1 minute walk from exit 6 of the Blue Line of Municipal Subway
There are numerous coin-operated parking spaces nearby (There are no affiliated parking lots)
Please bring your [parking ticket] from the Yokohama Station West Exit Underground Parking Lot and present it at the clinic reception desk when you arrive
You will receive a coupon for the time spent at the Hiro Clinic NIPT consultation (maximum 1 hour)
For more information, please contact the clinic reception
Only the Yokohama Station West Exit Underground Car Park is eligible for the discount

NIPT Hiro Clinic
Sapporo Ekimae

Web Reservation: 24 hours

Opening Hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒060-0003 3F N. Kita 3 Nishi 3 Building, 1-41, Kita 3 Nishi 3 Chome, Chuo-ku, Sapporo, Hokkaido

011-206-8330

NIPT Sapporo Ekimae Clinic (Hiro Clinic) MAP

1 min walk from Sapporo Station on the Subway Namboku Line
Numerous coin-operated parking spaces available nearby
(There are no affiliated parking lots)

NIPT Hiro Clinic
Sendai Ekimae

Web Reservation: 24 hours

Opening Hours

【Monday / Thursday / Friday / Saturday / Sunday】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒980-0021 7F Imon Sendai Ekimae Building, 1-8-40 Chuo, Aoba-ku, Sendai, Miyagi Prefecture

022-226-8718

NIPT Sendai Ekimae Clinic (Hiro Clinic) MAP

2-minute walk from JR Sendai Station
Numerous coin-operated parking spaces available nearby
(There are no affiliated parking lots)

NIPT Hiro Clinic
Nagoya Ekimae

Web Reservation: 24 hours

Opening Hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒453-0015 9F Principal Meieki Building, 16-19 Tsubaki-cho, Nakamura-ku, Nagoya, Aichi Prefecture

052-433-7736

NIPT Nagoya Ekimae Clinic (Hiro Clinic) MAP

3-minute walk from JR Nagoya Station
The nearest car park is Otake Parking.
When entering the garage, please take out a 【parking ticket】 and present it at the clinic reception.
Only Otake Parking is eligible for discounts.
You will receive a parking ticket for the time spent at the Hiro Clinic NIPT consultation. (Maximum of one hour)

NIPT Hiro Clinic
Osaka Ekimae

Web Reservation: 24 hours

Opening Hours

【 All days 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒530-0012 7F Umeda Seiwa Building, 2-6-30 Shibata, Kita-ku, Osaka City, Osaka

06-6131-8207

NIPT Osaka Ekimae Clinic (Hiro Clinic) MAP

5-minute walk from JR Osaka Station
3-minute walk from Osaka-Umeda Station
Please bring your parking ticket from the Umeda Seiwa Building with you when you visit the clinic, and we will stamp it with the reception seal for a 20% discount.

NIPT Hiro Clinic
Namba Shinsaibashi

Web Reservation: 24 hours

Opening Hours

【 Monday / Tuesday / Wednesday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒542-0085 7F Prime Square Shinsaibashi, 2-7-18 Shinsaibashisuji, Chuo-ku, Osaka

06-6226-8631

NIPT Namba Shinsaibashi Clinic (Hiro Clinic) MAP

4-minute walk from Namba Station on the Osaka Metro Midosuji Line
5-minute walk from Shinsaibashi Station on the Osaka Metro Midosuji Line, Exit 4-B
7-minute walk from Namba Station on JR Line

NIPT Hiro Clinic
Okayama Ekimae

Web Reservation: 24 hours

Opening Hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒700-0901 2F Sumiya Building, 1-2 Honmachi, Kita-ku, Okayama City, Okayama Prefecture

086-238-7874

NIPT Okayama Ekimae Clinic (Hiro Clinic) MAP

1 min walk from JR Okayama Station
The nearest car park is Q Parking (2-minute walk). Please bring your parking ticket with you when you visit the clinic and present it at the clinic reception to receive a one-hour parking fee. Only Q parking is eligible for the discount.

NIPT Hiro Clinic
Hakata Ekimae

Web Reservation: 24 hours

Opening Hours

【 Monday / Thursday / Friday / Saturday / Sunday 】

10:00 ~ 18:00

※The clinic is open even when the above-mentioned days are public holidays.

〒812-0013 OAK Hakata Building 501, 2-16-19, Hakata Station Higashi, Hakata-ku, Fukuoka City, Fukuoka Prefecture

092-292-6463

NIPT Hakata Ekimae Clinic (Hiro Clinic) MAP

6-minute walk from JR Hakata Station
The nearest car park is Times Hakata Ekigashi 2-chome No. 3. When entering Times, please issue a 【parking certificate】 and submit it to the clinic reception desk, and you will receive a parking fee for one hour. Only Times is eligible for discounts.

Clinic Search

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NIPT testing available at 115 locations nationwide

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Partner Clinics Information

You can undergo non-invasive prenatal testing at a nearby medical institution.

Nationwide Partner Medical Institutions

115 locations across 46 prefectures

*Available in all prefectures except Okinawa.
Hiro Clinic NIPT Nationwide Affiliated Medical Institutions

Find a nearby medical institution

Hokkaido Region

Hokkaido

  • Hiro Clinic NIPT Sapporo Ekimae Clinic
  • Asahikawa City
  • Hakodate City
  • Kushiro City

Tohoku Region

Miyagi Prefecture

  • Hiro Clinic NIPT Sendai Ekimae Clinic

Yamagata Prefecture

  • Yamagata City

Iwate Prefecture

  • Morioka City

Akita Prefecture

  • Akita City

Fukushima Prefecture

  • Iwaki City

Kanto Region

Ibaraki Prefecture

  • Mito City
  • Tsuchiura City

Gunma Prefecture

  • Maebashi City

Tochigi Prefecture

  • Utsunomiya City

Saitama Prefecture

  • Hiro Clinic NIPT Omiya Ekimae Clinic

Tokyo

  • Hiro Clinic NIPT Tokyo Ekimae Clinic
  • Hiro Clinic NIPT Shinjuku Ekimae Clinic

Chiba Prefecture

  • Katori City
  • Mobara City

Kanagawa Prefecture

  • Hiro Clinic NIPT Yokohama Ekimae Clinic

Chubu Region

Niigata Prefecture

  • Niigata City

Ishikawa Prefecture

  • Kanazawa City

Yamanashi Prefecture

  • Kofu City

Gifu Prefecture

  • Nakatsugawa City

Aichi Prefecture

  • Hiro Clinic NIPT Nagoya Ekimae Clinic

Toyama Prefecture

  • Toyama City
  • Imizu City

Fukui Prefecture

  • Fukui City

Nagano Prefecture

  • Nagano City
  • Matsumoto City

Shizuoka Prefecture

  • Shizuoka City

Mie Prefecture

  • Tsu City

Kinki Region

Shiga Prefecture

  • Kusatsu City

Kyoto Prefecture

  • Kyoto City

Osaka Prefecture

  • Hiro Clinic NIPT Osaka Ekimae Clinic
  • Hiro Clinic NIPT Namba Shinsaibashi Clinic

Nara Prefecture

  • Gojyo City

Hyogo Prefecture

  • Hiro Clinic NIPT Kobe Sannomiya Ekimae Clinic
  • Amagasaki City

Wakayama Prefecture

  • Wakayama City

Chugoku Region

Okayama Prefecture

  • Hiro Clinic NIPT Okayama Ekimae Clinic

Tottori Prefecture

  • Yonago City
  • Kurayoshi City

Yamaguchi Prefecture

  • Yamaguchi City

Shimane Prefecture

  • Matsue City

Hiroshima Prefecture

  • Kure City

Shikoku Region

Kagawa Prefecture

  • Takamatsu City

Kochi Prefecture

  • Kochi City

Tokushima Prefecture

  • Tokushima City

Ehime Prefecture

  • Matsuyama City

Kyushu Region

Oita Prefecture

  • Oita City

Fukuoka Prefecture

  • Hiro Clinic NIPT Hakata Ekimae Clinic

Nagasaki Prefecture

  • Nagasaki City
  • Higashisonogi District

Saga Prefecture

  • Saga City

Kumamoto Prefecture

  • Kumamoto City

Miyazaki Prefecture

  • Miyazaki City

Kagoshima Prefecture

  • Kagoshima City
* Testing is available in all prefectures except Okinawa.

NIPT testing at your local clinic

Please feel free to contact us

0120-99-6640

Phone reception hours: 9:00-21:00

Web予約はこちら 24時間対応

Medical Corporation Fukubikai
〒332-0017
Hiro Build. 3-11-27 Sakae-cho, Kawaguchi-shi, Saitama.
Hiro Clinic President: Hiroko Oka
TEL: 0120-16-9629.

Hiro Clinic Hiro Clinic