DNA analysis is a technique that analyzes an individual’s DNA (deoxyribonucleic acid) to prove parent-child relationships, to identify individuals, or to identify genetic characteristics. since DNA holds the genetic information of an organism and is unique to each individual, DNA analysis is a highly accurate means of identification. Below is a description of the significance and role of DNA testing.
1. Significance of DNA Analysis
DNA identification is of great significance in many areas of modern society. Its high reliability and accuracy make it the strongest evidence for personal identification.
a. Personal Identification
Because DNA is almost completely different in each individual, it is used as strong evidence in criminal investigations and identification situations. DNA testing, especially in forensic and crime scene settings, helps identify perpetrators and prevent false convictions.
b. Proof of parent-child relationship
In paternity testing, DNA testing is used to determine if the father or mother is indeed the biological parent of the child. This is very important in proving legal parent-child relationships and in disputes over inheritance, child support, etc.
c. Medical and genetic diagnosis
DNA testing is also used to diagnose and prevent hereditary diseases. Since certain genetic mutations are known to increase the risk of disease, it helps to achieve early diagnosis and personalized medicine.
2. The Role of DNA Analysis
DNA analysis plays an important role in a variety of areas, including
a. forensics
DNA analysis plays an important role in criminal investigations. DNA is extracted from blood, hair, and saliva left at crime scenes and used to identify the perpetrator. It is also used in many cases as evidence to solve false accusations.
b. Determination of parent-child relationship
In situations where legal verification of parent-child relationships is required (e.g., divorce, inheritance, immigration proceedings, etc.), DNA testing provides conclusive evidence and is frequently used in family courts and legal proceedings because it can determine biological parent-child relationships with greater than 99.99% accuracy.
c. Gene Therapy and Preventive Medicine
Through DNA analysis, it is possible to provide medical care based on an individual’s genetic information. This is especially important in the field of personalized medicine, where the risk of diseases caused by genetic mutations can be predicted and early treatment and preventive measures can be taken.
d. Archaeology and Historiography
DNA analysis is also used in archaeology and historical research. DNA analysis of ancient remains and mummies is used to confirm the identity of historical figures and to determine the genetic roots of ancient people.
3. Advantages of DNA Analysis
- High accuracy: Because DNA is unique to each individual, the accuracy of the test is extremely high, making personal identification and proof of parent-child relationships virtually assured.
- Small sample size: DNA can be analyzed from even the smallest sample (e.g., hair, saliva, blood, etc.).
- Wide range of applications: criminal investigations, medical care, parent-child relationship verification, archaeology, and many other fields.
4. History of DNA Analysis
The history of DNA testing has evolved along with advances in science and technology. The following is a timeline of the major events and developments.
Prior to 1980s
- 1869: Swiss biologist Friedrich Miescher first discovered DNA. However, its importance was not recognized at the time.
- 1953: James Watson and Francis Crick discovered the double helix structure of DNA in 1953.This revealed the mechanism by which DNA holds genetic information and is accurately replicated. Their work showed that DNA base pairs (adenine and thymine, guanine and cytosine) combine with each other to form a double helix, dramatically advancing our understanding of how genes are transmitted from parent to child. This discovery laid the foundation for molecular biology, for which he was later awarded the Nobel Prize in Physiology or Medicine, and contributed greatly to the development of modern genetics and biotechnology.
1980s
- 1984: British geneticist Sir Alec Jeffreys developed the DNA fingerprinting technique in 1984.This technique is a method of identifying individuals using DNA repeat sequences that differ from one individual to another. Jefferies’ findings are based on the fact that the short repeat sequences (so-called minisatellite sequences) in individual DNA have different patterns for each individual.
- 1985: The first legal DNA test was conducted using Jefferies’ technology. This identification led to the identification of the perpetrators of two murders in England and the release of an innocent suspect.
1990s
- 1990: In the United States, DNA testing is admitted as evidence in court for the first time. This led to the widespread use of DNA testing in legal proceedings.
- 1995: The establishment of the DNA database (NDNAD) in the United Kingdom dramatically increased the use of DNA testing in criminal investigations.
- 1996: The STR (short-strand repeat) analysis method was developed, allowing DNA profiling faster and more accurate than previous techniques.
2000s
- 2002: CODIS (Combined DNA Index System) became operational in the U.S., creating a database of federal and state criminal DNA profiles and improving investigative efficiency.
- 2003: The Human Genome Project was completed, completing the decoding of all human genetic information. This led to further development of DNA identification technology.
- 2008: Advances in Y-chromosome and mitochondrial DNA analysis techniques allow analysis of paternal and maternal genetic information.
2010s onwards
- 2013: Next-generation sequencing (NGS) technology became commercially available, dramatically increasing the speed and accuracy of DNA analysis.
- 2018: advances in techniques for analyzing low-frequency DNA profiles and mixed samples are being used in an even greater variety of criminal investigations and paternity tests.
- Today: DNA testing is used in a wide range of applications, including criminal investigations, verification of parent-child relationships, forensic science, and the medical field, and its accuracy and speed are improving every year due to technological advances.
Conclusion.
DNA identification plays an important role in a variety of fields, including forensic science, proof of parent-child relationships, and medicine. Its highly accurate identification capability has a wide range of applications, from criminal investigations to medical care, and even archaeological and historical research. On the other hand, it is also associated with privacy and ethical issues, and appropriate operations are required to take these into account.
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Supervisor of the article
Dr. Hiroshi Oka
Graduated from Keio University, Faculty of Medicine
Doctor of Medicine
Medical Doctor
