Features of Hiro Clinic’s Prenatal DNA Testing

Safe, Secure, and Quick Prenatal DNA Testing

Achieved pricing through full automation. That’s why we offer amazing prices!
With a fully automated system that reduces labor costs, you receive affordable, fast, and accurate results.
From sample collection to testing using barcodes, there are no sample mix-ups. Additionally, samples are sent directly from medical institutions, so there’s no worry about loss.
Peace of mind you can only get from a clinic. Our doctors provide thorough consultations and explanations.
As a certified testing facility, we ensure stable and reliable result reporting.

What is MiSeq FGx System?

This is Japan’s first prenatal parent-child DNA test using the MiSeq FGx System developed by Qiagen Corporation. It is the most widely used testing machine worldwide. The MiSeq FGx System has been in use globally since 2015, with a proven track record of 100,000 tests. It is a machine from a highly trusted company.

Main Features:
Specialized for Forensics: The MiSeq FGx is designed to meet the specific needs of forensic science, providing reliable results even from trace or degraded DNA samples.

High-Precision Sequencing: It can accurately analyze large amounts of DNA data in a short time, making it suitable for personal identification, parentage testing, and forensic analysis.

Open and Flexible System: The MiSeq FGx is compatible with existing forensic protocols and databases, allowing it to integrate with other forensic systems. It also offers flexible customization to support various analytical purposes.

Compact and Fast: The system is compact and delivers results quickly, making it useful for immediate responses in laboratory settings and reducing backlogs.

Tokyo Sanitary Laboratory

Tokyo Sanitary Laboratory is registered as a sanitary laboratory in Japan and has dedicated doctors. You can feel secure undergoing tests here because it is a testing facility operated under medical supervision.

Tokyo Sanitary Laboratory is a genetics-focused sanitary laboratory equipped with five next-generation sequencers. It is certified with CAP and ISO 9001, ensuring safe and secure testing, audited by third-party organizations.

Three types of samples, so it’s a triple!

The “Triple Test” uses three types of samples, which increases the accuracy of the test compared to using only two types of samples. Since DNA from the mother contains both fetal and maternal components, there can be errors that arise. By using three types of samples, we can obtain DNA purely from the mother, allowing for a more stable and accurate test.

  • Father’s DNA (cheek swab)
  • Mother’s DNA (cheek swab)
  • Fetal DNA (mother’s blood sample)

Comparison of Test Sites

Testing PeriodSTR (Autosomal and X Chromosomes)STR (Y Chromosome)
NIPPTFrom 6th week of pregnancy2824
Comparison of Test Sites

Tokyo Sanitary Laboratory’s Testing Method Using STR

What is STR?

Humans typically have two chromosomes. Chromosomes 1 through 22 are called autosomes, and in addition to these, there are sex chromosomes. Altogether, there are 46 chromosomes. Within some of these, there are unique repeating regions characteristic of each individual, where the number of repeats varies from person to person.
For example, let’s say the number of repeats for Chromosome 1 in the mother is 12 and 13.
In the same location for the father, it could be 15 and 17. The reason there are two values is because there are two Chromosome 1s. The baby born from these two parents will inherit a combination of these repeats.

  • 12 and 15
  • 13 and 15
  • 12 and 17
  • 13 and 17

There are only four possible patterns.

If any other pattern is detected, it is determined that the father is different. There are more than ten such repeat counts at each genetic location. In the Triple Test, we examine at least 22 locations.
This means there is a less than one in 1027 chance of error.

Fraction or less.

Not Applicable for Testing

Multiple fetuses (twins or more)
Vanishing Twin

Testing for twin fetuses is currently not available.

Testing Limitations

It is not possible to distinguish if identical twins are present in the subject.
Additionally, there are rare cases of genetic complexities, such as maternal mosaicism, which means that it is not possible to achieve 100% accuracy in any identification.