ED（勃起不全）治療における組織工学ED

International Index of Erectile Function (IIEF)

The International Index of Erectile Function (IIEF) is a common index used to evaluate the degree of erection. In particular, the Erection Hardness Score (EHS) is used to score and evaluate the hardness of an erection: Score 1: Penis enlarged but not hardened.Score 2: Penis hardens but does not fully harden.Score 3: Penis hardens sufficiently but does not become fully erect.Score 4: Fully hard and fully erect.This score helps to quantitatively measure the quality of erection for clinical diagnosis and evaluation of treatment efficacy. Physicians...
筋トレED

What is the measure of the quality of intercourse?

Indicators of the quality of sexual intercourse are based primarily on individual satisfaction, but there are also several methods used in scientific research and clinical diagnosis. These indicators have been developed to objectively assess sexual function and satisfaction. 1. Self-report questionnaire on sexual function One of the most common ways to measure the quality of intercourse is to use self-report questionnaires. This includes the following: 2. Sexual Satisfaction Scale There are also scales specifically designed to assess sexual satisfaction. These include numerical ratings of post-sexual...
ナースED

Premature Ejaculation and ED Drugs

Premature ejaculation and erectile dysfunction (ED) are both sexual dysfunctions, but they occur through different mechanisms. Nevertheless, there can be an indirect link between them. What is premature ejaculation? Premature ejaculation is a condition in which ejaculation occurs extremely quickly during intercourse, which may involve psychological or neurophysiological factors. In some men, premature ejaculation can result from performance anxiety or sexual tension. What is Erectile Dysfunction (ED)? Erectile dysfunction is the inability to achieve or maintain an erection necessary for adequate sexual activity; causes of...
女医ED

Relationship between true foreskin and ED

While a true foreskin generally does not directly affect erections, in some cases it can make sexual activity painful. A true foreskin is a condition in which the glans is completely covered by the foreskin and cannot be peeled by hand. This condition itself does not prevent erection, but the foreskin is so narrow that it can cause pain during erection. The mechanism of erection is by blood flowing into the corpora cavernosa of the penis and causing its tissues to swell.In the case of...
陰茎の構造についてED

The Structure of the Penis

The penis is the passageway for urine and sperm and is an important organ for sexual function. The main structure of the penis consists of three parts 1. Sponge It consists of the urethral sponge, which runs down the center of the penis, and the penile spongiosa on either side of it.These corpora cavernosa are spongy tissues with numerous cavities, and an erection occurs when these cavities fill with blood upon sexual arousal. 2. Urethra The urethra is a tube that runs vertically down the...
薬関連疾患

Pulmonary Hypertension and PDE5

Pulmonary Hypertension (PH) is a condition in which the blood pressure in the pulmonary arteries becomes abnormally high, which places an excessive burden on the heart and can eventually lead to heart failure. This condition occurs when the walls of the pulmonary arteries become thickened, stiffened, or narrowed, restricting blood flow. Pulmonary hypertension is characterized by symptoms such as shortness of breath during exercise, chest pain, fatigue, and dizziness. Five-year survival rates for pulmonary arterial hypertension (PAH) vary widely depending on the type of disease...
東洋と西洋における性交回数の比較治療法

What is PDE5?

The PDE5 (phosphodiesterase type 5) enzyme is an important enzyme, especially active in the smooth muscle cells of the penis, responsible for the breakdown of the molecule cGMP (cyclic guanosine monophosphate). cGMP promotes relaxation of vascular smooth muscle and increases blood flow to blood flow, thereby assisting in erection. Below is a more detailed description of the PDE5 enzyme and its biological importance. Role of PDE5 enzymeDegradation of cGMP: PDE5 is responsible for degrading cGMP, which terminates the biological effects of cGMP. cGMP is produced...
バルデナフィルの構造式カテゴリーなし

Structural formula of Vardenafil

Vardenafil (Vardenafil) is a phosphodiesterase type 5 (PDE5) inhibitor, primarily used to treat erectile dysfunction (ED).It is known on the market under brand names such as Levitra and Staxyn. These drugs work by improving blood flow to support an erection. Molecular Structure of Vardenafil The chemical formula of vardenafil is C23H32N6O4S and has the following structural characteristics Sequence of actions Vardenafil, like sildenafil and tadalafil, inhibits the activity of the PDE5 enzyme. This enzyme degrades cGMP in penile tissue. cGMP promotes vasodilation and smooth muscle...