Tadalafil is a medication used to treat erectile dysfunction (ED), dysuria associated with benign prostatic hyperplasia, and pulmonary arterial hypertension. There are certain precautions and precautions that should be taken when taking this medication in combination with certain medications. Below is a list of medications that should not be taken with tadalafil and what to watch out for while taking it.
Medications not to be taken together
Nitrates (e.g. nitroglycerin)Medications not to be taken together
Nitrates (e.g. nitroglycerin)
Nitrates are used to treat angina pectoris and other conditions. The combination of tadalafil and nitrates can cause a sudden and potentially dangerous drop in blood pressure. This is especially true for drugs such as nitroglycerin, isosorbide dinitrate, and amylnitrite.
Riociguat (a drug for the treatment of pulmonary arterial hypertension)Nitrates are used to treat angina pectoris and other conditions. The combination of tadalafil and nitrates can cause a sudden and potentially dangerous drop in blood pressure. This is especially true for drugs such as nitroglycerin, isosorbide dinitrate, and amylnitrite.
Riociguat (a drug for the treatment of pulmonary arterial hypertension)
The combination ofriociguat and tadalafil may cause a significant decrease in blood pressure and should be avoided.
Alpha-blockers
Concomitant use with alpha-blockers (doxazosin, tamsulosin, etc.) used to treat hypertension and benign prostatic hyperplasia carries the risk of a sudden drop in blood pressure.Unless directed by a physician, concomitant use with these medications should be avoided or used with caution.
Some antifungal and antiviral drugs
Certain antifungal and HIV medications, such as ketoconazole and ritonavir, slow the breakdown of tadalafil and increase its concentration in the blood. Consult your physician if you are taking these medications concomitantly.
Be careful while taking
Alcohol Consumption
Consuming large amounts of alcohol may cause a drop in blood pressure, which may lead to dizziness and headaches. Excessive alcohol intake should be avoided while taking tadalafil.
Grapefruit juice
Grapefruit juice may slow the breakdown of tadalafil and increase its concentration in the blood. This may result in stronger side effects, so it is recommended that grapefruit intake be avoided while taking the drug.
Sustained erection (priapism)Grapefruit juice may slow the breakdown of tadalafil and increase its concentration in the blood. This may result in stronger side effects, so it is recommended that grapefruit intake be avoided while taking the drug.
Sustained erection (priapism)
If an erection lasting longer than 4 hours occurs, urgent medical attention is required. Priapism can lead to permanent erectile dysfunction if treatment is delayed.
Visual and auditory changes
Any visual or hearing problems after taking the drug, especially if there is sudden loss of vision, blindness, or hearing loss, requires immediate medical attention.
Conclusion
It is important to avoid concomitant use of certain medications (especially nitrates and alpha-blockers) while taking tadalafil. Also, be careful with alcohol and grapefruit juice, and consult your doctor immediately if you experience persistent erections or visual or auditory abnormalities. It is always important to consult a physician or pharmacist before taking the drug to check for interactions with your medical conditions or other medications.
