Androgenetic alopecia (AGA) is a common problem faced by many men. There are various options for treating AGA, but a combination of oral and topical drugs is widely recognized as an effective treatment method. This article provides a detailed explanation of the effects of AGA treatment using a combination of oral and topical drugs.
1. Basic understanding of AGA
1.1 What is AGA?
AGA is a progressive hair loss disease caused by genetics and the influence of male hormones. It is characterized by the fact that the hair on the front and top of the head tends to thin, and it progresses quickly. With appropriate treatment, it is possible to slow the progression of hair loss and encourage hair regrowth.
1.2 Causes of AGA
AGA is mainly caused by the following factors:
Genetics: AGA has a strong genetic component, and if someone in your family has AGA, your risk increases.
Hormones: The hormone DHT (dihydrotestosterone) acts on the hair follicles and inhibits hair growth.
2. Effects of oral medications
2.1 Finasteride (Propecia)
What it does: Finasteride inhibits the enzyme 5α-reductase, which prevents testosterone from being converted to DHT. This reduces the effect of DHT on hair follicles and suppresses the progression of hair loss.
Directions for use: Take 1 mg orally once daily. Continuous use is required, and it may take 3 to 6 months for effects to appear.
Side effects: Side effects such as decreased libido and erectile dysfunction have been reported in some users, but are rare.
2.2 Dutasteride (Zagaro)
Effects: Dutasteride inhibits 5α-reductase over a broader range than finasteride and suppresses DHT production more effectively. This makes it effective even when finasteride is insufficiently effective.
Directions for use: Take 0.5mg orally once daily. It may take about 3 to 6 months for the effects to appear.
Side effects: Side effects such as decreased libido and erectile dysfunction have been reported, but are rare.
3. Effects of topical medicines
3.1 Minoxidil (Reup)
Effects: Minoxidil dilates blood vessels and improves blood flow to the scalp, making it easier to supply nutrients to hair follicles. This promotes hair growth and returns the resting hair follicles to the anagen phase.
How to use: Apply directly to areas where you are concerned about thinning hair twice a day. It may take about 3 to 6 months for the effects to appear.
Side effects: Side effects such as itching and dryness of the scalp and early hair loss have been reported, but are usually mild.
4. Effects of combined use of oral and external drugs
4.1 Mechanism of synergy
By using oral and topical drugs together, a synergistic effect can be expected in AGA treatment. Oral medications suppress the production of DHT and prevent the progression of hair loss. On the other hand, topical medications improve blood flow to the hair follicles and promote hair growth. This can reduce hair loss while promoting new hair growth.
4.2 Results of clinical research
Clinical studies have shown that a combination of oral and topical medications is more effective than using them alone. Below are some of them:
Study 1: The combination of finasteride and minoxidil significantly increased hair density after 6 months compared to using it alone.
Study 2: The combination of dutasteride and minoxidil significantly improved hair thickness after 12 months compared to using alone.
5. How to practice combination therapy
5.1 How to make a treatment plan
For AGA treatment to be successful, it is important to have an appropriate treatment plan. Get checked by a specialist and plan accordingly, considering the following points:
Choice of oral medication: Choose either finasteride or dutasteride. We will determine the most appropriate medication under the guidance of a specialist.
Choice of topical medication: Use minoxidil and apply directly to the scalp. Recommended use twice a day.
Continuation of treatment: A combination of oral and topical drugs will be continued, and the effects will be evaluated after 3 to 6 months. If the effect is confirmed, further treatment will be continued.
5.2 Management of side effects
Management of side effects is also important in combination therapy. Pay attention to the following points and consult a specialist if you experience any side effects:
Side effects of oral medication: Decreased sexual desire and erectile dysfunction have been reported. If you experience strong side effects, consult a specialist and change the medication or adjust the dose.
Side effects of topical medications: Itching and dryness of the scalp have been reported. If the symptoms are severe, adjust the frequency of use or use a moisturizer together.
5.3 Review of lifestyle habits
Maintaining a healthy lifestyle is also important to maximize the effectiveness of your treatment. Please review your lifestyle by paying attention to the following points:
Nutritionally balanced diet: Consume nutrients necessary for healthy hair, such as B vitamins, zinc, and iron.
Moderate exercise: Incorporate moderate exercise to promote blood circulation.
Get enough sleep: Ensure good quality sleep and support your overall health.
Stress management: Reduce stress by practicing relaxation techniques and making time for hobbies.
In conclusion
A combination of oral and topical drugs is very effective in treating AGA. A synergistic effect can be expected, with oral medications suppressing DHT production and topical medications promoting hair growth. It is important to consult a specialist and develop an appropriate treatment plan. Also, make sure to review your lifestyle and manage side effects to maximize the effectiveness of your treatment. By continuing treatment from a long-term perspective, it is possible to regain healthy hair.
AGA treatment at Hiro Clinic
AGA (Androgenetic Alopecia) is a disease called male pattern baldness, which progresses if left untreated, so early treatment is necessary. The causes of AGA vary depending on the individual, but it is not a disease that cannot be treated. Hiro Clinic uses cutting-edge regenerative medicine technology to treat AGA. Our specialized doctors will suggest appropriate treatment methods tailored to each individual and will do their best to support your concerns.
